Antidiabetic and Antiobesity Effects of Artemether in db/db Mice

Figure 2

Effects of artemether on glucose and glucose tolerance in db/db mice. Ten-week-old mice were treated with 1% methylcellulose or with artemether (200 mg/kg) for two weeks. Intraperitoneal glucose tolerance tests (IPGTT) (1 g/kg) and fasting glucose were performed after overnight fasting. (a) shows the fasting blood glucose levels; , versus DM group. (b) shows intraperitoneal glucose tolerance test of mice at the start of experiment. Means and SEM are indicated for 4-5 animals from each group. (c) shows the area under the curve from the glucose tolerance test described in (b). (d) shows intraperitoneal glucose tolerance test of mice after the treatment of artemether. (e) shows the area under the curve from the glucose tolerance test described in (d). Measurements in individual animals are shown, and the means and SEM are indicated for the groups; , versus NC group, and , versus artemether group in (c).

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