The Diverse Mechanisms of miRNAs and lncRNAs in the Maintenance of Liver Cancer Stem Cells

Figure 1

The diverse regulatory mechanisms of ncRNAs on Wnt signaling pathway. (A) Let7b can target and silence FZD4 expression. (B) miR-148a can inhibit the expression of ACVR1 to block the formation of Wnt-FZD-LRP5/6 receptor complex. (C) miR-1246 can directly suppress AXIN2 and GSK3β expression. (D) miR-200a can silence the expression of β-catenin. (E) miR-214 can deplete β-catenin expression. (F) miR-612 can indirectly decrease the nuclear accumulation of β-catenin. (G) miR-181 can enhance TCF activity by decreasing its inhibitor NLK. (H) Let-7a can directly silence TCF4. (I) lnc-β-Catm can lead to the methylation of β-catenin, enhancing the stability of β-catenin protein. (J) lncRNA-DANCR can bind to 3′-UTR of β-catenin to increase its expression by preventing β-catenin from depletion by miR-214 and miR-320a. (K) lnc-TCF7 can recruit SWI/SNF complex to TCF7 promoter and further elevate the activation of TCF7.