Chronic Unpredictable Mild Stress Causing Cardiac and Thoracic Spinal Cord Electrophysiological Abnormalities May Be Associated with Increased Cardiac Expression of Serotonin and Growth-Associated Protein-43 in Rats
General procedure in this study. The nine types of environmental stressors for the CMS group. (1) Behavior restrictions; (2) overnight lighting; (3) tilted cage for 24 h; (4) clustered feeding; (5) ice water swimming; (6) day and night reversal; (7) soiled cage; (8) wet cage; and (9) noise stimulation. The stressful stimulus was given at 8:00 a.m. every morning, and the stimuli were applied in a random order to ensure the animals could not predict the stimulus to be used. A total of nine types of stimuli were applied, and the stimulus type was randomly assigned each day. The control group of animals was housed for the same period of time (three weeks) without exposure to stressful stimuli. /group.
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