Discriminative and Quantitative Analysis of Antineoplastic Taxane Drugs Using a Handheld Raman Spectrometer

Table 2

Results coming from the validation of the Raman method developed to quantify taxane drugs in sodium chloride solution.

	CBX	PCX	DCX
Range of linearity (mg/mL)	0.175 – 0.30	0.57 – 1.20	0.40 – 1.00
Slope	1.0001	0.9598	0.9917
Intercept	7.10^−6	0.0252	0.0048
R^2	0.9999	0.9598	0.9909
LOQ (mg/mL)	0.16	0.56	0.40
Relative bias (%)
Level 1	0.3	6.1	−1.4
Level 2	−2.2	5.1	−4.2
Level 3	−0.2	−1.2	−5.3
Repeatability (RSD %)
Level 1	7.6	2.6	3.2
Level 2	2.5	1.7	2.3
Level 3	5.4	1.7	1.6
Intermediate precision (RSD %)
Level 1	10.7	8.6	5.2
Level 2	3.9	1.8	2.7
Level 3	5.4	1.8	2.5
β-Expectation tolerance limit (%)
Level 1	[−24.7;25.3]	[−22.8; 35.0]	[14.5; 11.7]
Level 2	[−11.6; 7.2]	[1.5; 8.8]	[−9.8; 1.5]
Level 3	[−10.8; 10.4]	[−4.7; 2.2]	[−11.1; 0.4]