Stromal Cell-Derived Factor-1<i>α</i> Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps

<div>Schematic diagram of the interaction between SDF-1<i>α</i>/CXCR4 and CaSR. Activation of CaSR increased the expression of Bax, then Cyt-c, caspase-9, and cleaved caspase-3; it finally caused cell apoptosis. Activation of the SDF-1<i>α</i>/CXCR4 axis alleviated this process as Bcl-2.</div>

BioMed Research International

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Figure 5

Figure 5: Stromal Cell-Derived Factor-1<i>α</i> Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps 

Figure 5 | Stromal Cell-Derived Factor-1α Alleviates Calcium-Sensing Receptor Activation-Mediated Ischemia/Reperfusion Injury by Inhibiting Caspase-3/Caspase-9-Induced Cell Apoptosis in Rat Free Flaps 