Mutational Profiling of Non-Small-Cell Lung Cancer Resistant to Osimertinib Using Next-Generation Sequencing in Chinese Patients

Table 3

Mutation types and mutant allele fraction (MAF) (%) changes.

#1				#5
Before osimertinib		After osimertinib		Before osimertinib		After osimertinib
Mutation	Rate	Mutation	Rates	Mutation	Rates	Mutation	Rates
L858R	42.9	L858R	63.2	19 del	9.6	19 del	2.1
IL7R	19.1	IL7R	31.5	T790M	1.1	PIK3CA	1.8
T790M	5.7	TENM3	27.1	TP53	7.11	TP53	1.7
CCND3	5.8	CCND3	14.3			RNASEL	1.2
WSCD2	5.1	ROS1 (6737 G>A)	2.9			TET2	0.8
FGR3A	4.1	FGFR3	1.9			MAP3K1	0.8
		XPC	1.5
		ATM	1.5
		FAM135B	1.2
		PALB2	1.1
		MLL	1
		ROS1 (1611A>G)	1
		CDKN2A	0.2
		Altered copy
		CDKN2B DEL	0.3
		CDKN2A DEL	0.2