Plumbagin-Loaded Nanoemulsion Drug Delivery Formulation and Evaluation of Antiproliferative Effect on Prostate Cancer Cells

<table class="fixed-width table-group" id="tab1"><tr><td><table class="table"><colgroup><col style="width:7.21em"/><col style="width:6.07em"/><col style="width:6.05em"/><col style="width:6.31em"/><col style="width:7.04em"/></colgroup><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2"> </td><td class="align_center" rowspan="2">Water</td><td class="align_center" rowspan="2">HCl 0.1 M</td><td class="align_center" colspan="2">0.01 M NaH<sub>2</sub>PO<sub>4</sub>/Na<sub>2</sub>HPO<sub>4</sub></td></tr><tr class="thead"><td class="align_center">pH 6.8</td><td class="align_center">pH 7.5</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td class="align_left">NE, empty</td><td class="align_center">134.5 (0.111)</td><td class="align_center">134.2 (0.115)</td><td class="align_center">126.6 (0.127)</td><td class="align_center">158.8 (0.177)</td></tr><tr><td class="align_left">NE-PL, loaded</td><td class="align_center">135.1 (0.166)</td><td class="align_center">135.2 (0.101)</td><td class="align_center">135.7 (0.088)</td><td class="align_center">185.7 (0.149)</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Changes in particle size distribution after dispersion of nanoemulsions in media simulating physiological conditions. Control, empty (NE), and plumbagin-loaded (NE-PL) nanoemulsions (3.5% polysorbate 80) were dispersed in indicated media (1000 x dilution) and incubated for 24 h at 37°C. The particle size distribution was determined by DLS. PDI values are indicated in brackets.</div>

BioMed Research International

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Table 1

Table 1: Plumbagin-Loaded Nanoemulsion Drug Delivery Formulation and Evaluation of Antiproliferative Effect on Prostate Cancer Cells 