Adaptation and Constraint in the Atypical Chemokine Receptor Family in Mammals

Table 1

Likelihood ratio test statistics for models of variable selective pressure among sites.

Gene	Model	Parameters	Models compared	LRT(2Δl)	P-value	df	Positively selected sites (BEB)
ACKR1	M0	ω0=0.43574	M0 vs M3	534.02	0.0000	4
	M3	ω0=0.03476 ω1= 0.35759; ω2= 1.15972
		p0= 0.23127 p1= 0.47276; p2= 0.29597
	M1a	ω0=0.16327 ω1=1.00000	M1a vs M2a	0	1.0000	2
		p0=0.55005 p1=0.44995
	M2a	ω0=0.16327 ω1= 1.00000; ω2=1.00000
		p0=0.55005 p1=0.28372; p2=0.16623
	M7	p =0.53074 q=0.60339	M7 vs M8	21.26	0.0000	2	154
	M8	p0=0.85617 p=0.68793; q=1.15451
		p1=0.14383 ω=1.45019
ACKR2	M0	ω0=0.20556	M0 vs M3	652.48	0.0000	4
	M3	ω0=0.01987 ω1=0.21352; ω2= 0.77475
		p0= 0.34607 p1=0.48100; p2= 0.17293
	M1a	ω0=0.12737 ω1=1.00000	M1a vs M2a	0	1.0000	2
		p0=0.79265 p1=0.20735
	M2a	ω0=0.12737 ω1= 1.00000; ω2=1.00000
		p0=0.79265 p1=0.18741; p2=0.01994
	M7	p =0.52179 q=1.61923	M7 vs M8	8.88	0.0117	2
	M8	p0=0.97423 p=0.59529; q=2.13409
		p1=0.02577 ω=1.39256
ACKR3	M0	ω0=0.04691	M0 vs M3	569.64	0.0000	4
	M3	ω0=0.00786 ω1=0.12501; ω2= 0.49733
		p0= 0.71583 p1=0.24584; p2=0.03833
	M1a	ω0=0.03806 ω1=1.00000	M1a vs M2a	0	1.0000	2
		p0=0.95014 p1=0.04986
	M2a	ω0=0.03806 ω1= 1.00000; ω2=28.52785
		p0=0.95014 p1=0.04986; p2=0.00000
	M7	p =0.24148 q=3.44384	M7 vs M8	7.78	0.0204	2
	M8	p0=0.98766 p=0.27944; q=5.15904
		p1=0.01234 ω=1.00000
ACKR4	M0	ω0=0.12972	M0 vs M3	416.55	0.0000	4
	M3	ω0=0.03081 ω1=0.32186; ω2=1.16947
		p0= 0.65355 p1=0.33146; p2=0.01499
	M1a	ω0=0.08280 ω1=1.00000	M1a vs M2a	0	1.0000	2
		p0=0.84629 p1=0.15371
	M2a	ω0=0.08280 ω1= 1.00000; ω2=31.41467
		p0=0.84629 p1=0.15371; p2=0.00000
	M7	p =0.41473 q=2.39665	M7 vs M8	5.54	0.0626	2	139
	M8	p0=0.99543 p=0.43468; q=2.65383
		p1=0.00457 ω=1.77610