Secondary Degeneration of Auditory Neurons after Topical Aminoglycoside Administration in a Gerbil Model

Figure 6

SGC densities at four different parts of the cochlea at 4 (a) and 12 weeks (b) after drug administration. The KP group showed no significant decrease in SGC densities compared to the control at both 4 and 12 weeks. The KG group showed a significant SGC density decrease at all locations at both time points. The KI group showed a significant SGC density decrease at all locations at the 4-week time point but did not show a significant decrease at the 12-week time point. All units in the plot (black dot: control; green square: KP; blue triangle: KG; red inverted triangle: KI) represent individual subjects. The three groups were kanamycin percutaneous (KP), kanamycin gelfoam (KG), and kanamycin RW injection (KI). The asterisk () indicates a value lower than .05, the double asterisk () indicates a value lower than .01, and the triple asterisk () indicates a value lower than .001.

(a)

(b)