Developmental Programming of Capuchin Monkey Adrenal Dysfunction by Gestational Chronodisruption

Figure 1

Effect of exposure to constant light during the last third of gestation on plasma DHAS and cortisol in response to ACTH in 1-month-old and 10-month-old infants after dexamethasone treatment (see text for details). Mean ± SEM DHAS concentration (μg/mL) in (A) 1-month-old and (C) 10-month-old infants from mothers under control (n=4) and LL (n=4) conditions (14:10 light:dark, solid line, and closed circles and constant light during late gestation, broken line, and open circles, respectively). Mean ± SEM cortisol concentration (μg/mL) in (B) 1-month-old and (D) 10-month-old infants from mothers under control (n=4) and LL (n=4) conditions (14:10 light:dark, solid line, and closed circles and constant light during late gestation, broken line, and open circles, respectively). Different to control (P<0.05; Student’s t-test). ^&Different to basal concentration (P< 0.05; ANOVA for repeated measures and Newman-Keuls test). Please note that for 1-month-old infants, plasma DHAS concentrations in basal conditions and in response to ACTH in LL were different to control infants (P< 0.05; two-way ANOVA for repeated measures and Bonferroni test).