Peripheral Blood Lymphocyte-to-Monocyte Ratio as a Useful Prognostic Factor in Newly Diagnosed Multiple Myeloma

Table 2

Univariate and multivariate analyses for OS.

Prognostic factors	Univariate analysis		Multivariate analysis
	HR (95% CI)	P	HR (95% CI)	P
Age ≥ 65 years	1.045 (0.630-1.733)	0.866
Hemoglobin < 100g/L	1.305 (0.820-2.078)	0.262
Serum albumin < 35g/L	1.381 (0.840-2.272)	0.203
Serum LDH ≥ 250U/L	2.748 (1.661-4.548)	< 0.001	1.775 (0.984-3.199)	0.056
Serum creatinine ≥ 177umol/L	1.953 (1.178-3.238)	0.009	1.138 (0.591-2.192)	0.699
Serum calcium ≥ 2.75mol/L	2.761 (1.371-5.559)	0.004	1.427 (0.657-3.102)	0.369
Serum β2-microglobulin ≥ 5.5mmol/L	2.410 (1.523-3.815)	< 0.001	1.810 (1.049-3.125)	0.033
1q21 gain	1.714 (1.086-2.704)	0.021	1.527 (0.957-2.436)	0.076
del (17p)	1.526 (0.803-2.902)	0.197
t (4;14)	1.009 (0.501-2.033)	0.980
t (11;14)	1.431 (0.830-2.465)	0.197
t (14;16)	1.910 (0.695-5.246)	0.210
LMR ≤ 4.2	2.207 (1.356-3.591)	0.001	1.703 (1.020-2.842)	0.042

Abbreviations: CI, confidence interval; HR, hazard ratio; LDH, lactate dehydrogenase; LMR, lymphocyte-to-monocyte ratio; OS, overall survival