Epidermal Growth Factor Relieves Inflammatory Signals in<i> Staphylococcus aureus</i>-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in Nc/Nga Mice

<div><i>Topical epidermal growth factor (EGF) reduced thymic stromal lymphopoietin (TSLP) expression and increased mBD-3 expression in 2,4-dinitrochlorobenzene- (DNCB-) induced AD-like skin lesions</i>. Immunohistochemical staining of TSLP and mBD-3 (high-power field, ×400). (a) There was reduced expression of TSLP in both the EGF and pimecrolimus groups compared with the positive control group at 6 h. TSLP expression was reduced much more in the EGF group than in the pimecrolimus group. (b) mBD-3 expression was induced in the EGF group at 1 h.</div>

BioMed Research International

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Figure 5: Epidermal Growth Factor Relieves Inflammatory Signals in<i> Staphylococcus aureus</i>-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in Nc/Nga Mice 

Figure 5 | Epidermal Growth Factor Relieves Inflammatory Signals in Staphylococcus aureus-Treated Human Epidermal Keratinocytes and Atopic Dermatitis-Like Skin Lesions in Nc/Nga Mice 