Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development
Table 2
Genotyping and allele frequency of RETN single nucleotide polymorphisms in oral squamous cell carcinoma and cancer-free, healthy males (controls).
Variable
Controls (N=1,200)
Patients (N=935)
OR (95% CI)
AOR (95% CI)
rs3745367
GG
461 (38.4%)
349 (37.3%)
1.000 (reference)
1.000 (reference)
GA
561 (46.8%)
449 (48.0%)
1.057 (0.877-1.274)
1.132 (0.888-1.444)
AA
178 (14.8%)
137 (14.7%)
1.017 (0.782-1.322)
1.066 (0.755-1.506)
GA+AA
739 (61.6%)
586 (62.7%)
1.047 (0.878-1.249)
1.116 (0.887-1.406)
rs7408174
TT
603 (50.3%)
499 (53.4%)
1.000 (reference)
1.000 (reference)
TC
497 (41.4%)
369 (39.5%)
0.897 (0.750-1.074)
0.891 (0.705-1.126)
CC
100 (8.3%)
67 (7.1%)
0.810 (0.581-1.128)
0.901 (0.588-1.380)
TC+CC
597 (49.7%)
436 (46.6%)
0.883 (0.744-1.047)
0.893 (0.714-1.116)
rs1862513
GG
443 (36.9%)
352 (37.7%)
1.000 (reference)
1.000 (reference)
GC
575 (47.9%)
452 (48.3%)
0.989 (0.821-1.192)
0.991 (0.777-1.265)
CC
182 (15.2%)
131 (14.0%)
0.906 (0.696-1.181)
0.908 (0.644-1.280)
GC+CC
757 (63.1%)
583 (62.3%)
0.969 (0.812-1.157)
0.971 (0.771-1.223)
rs3219175
GG
761 (63.4%)
590 (63.1%)
1.000 (reference)
1.000 (reference)
GA
397 (33.1%)
304 (32.5%)
0.988 (0.822-1.187)
0.918 (0.722-1.168)
AA
42 (3.5%)
41 (4.4%)
1.259 (0.808-1.962)
0.994 (0.559-1.767)
GA+AA
439 (36.6%)
345 (36.9%)
1.014 (0.849-1.210)
0.926 (0.735-1.168)
The adjusted odds ratios (AORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression models that controlled for betel quid chewing, tobacco smoking, and alcohol consumption.
