Association of Resistin Gene Polymorphisms with Oral Squamous Cell Carcinoma Progression and Development

Table 6

Combined effect of betel quid chewing and RETN haplotypes on OSCC development.

Betel quid chewing	RETN haplotype	Controls	Patients	AOR (95% CI)
		n = 2400	n = 1870
Yes	A-T-G-G	33 (1.4%)	179 (9.6%)	18.390 (12.333-27.421)
Yes	Others	365 (15.2%)	1311 (70.1%)	12.774 (10.666-15.300)
No	A-T-G-G	224 (9.3%)	47 (2.5%)	1.203 (0.856-1.690)
No	Others	1778 (74.1%)	333 (17.8%)	1.000 (reference)

Other haplotypes included G-T-G-G, G-C-G-G, A-T-C-A, A-T-C-G, G-T-C-G, G-T-C-A, A-C-C-A, G-C-C-G, A-C-G-G, A-C-C-G, G-C-C-A, A-T-G-A, and G-C-G-A.
Multivariate analysis adjusted for the effects of tobacco smoking and alcohol consumption.
p<0.001.
OSCC: oral squamous cell carcinoma.