The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates Colorectal Carcinogenesis and Prognosis

Table 1

Basic characteristics and function of key NER pathway genes.

Gene	Location	Exon	Protein mass	Step	Biological function
ERCC1	19q13.32	14	33 kDa	Incision	Incision of damaged DNA at 5′ site by forming XPF-ERCC1 heterodimer
ERCC2 (XPD)	19q13.32	24	86 kDa	Unwinding	5′-3′ unwinding of the DNA strands of the damaged site
ERCC3 (XPB)	2q14.3	15	89 kDa	Unwinding	3′-5′ unwinding of the DNA strands of the damaged site
ERCC4 (XPF)	16p13.12	13	104 kDa	Incision	Incision of damaged DNA at 5′ site by forming XPF-ERCC1 heterodimer
ERCC5 (XPG)	13q33.1	15	133 kDa	Incision	Incision of damaged DNA at 3′ site
ERCC6 (CSB)	10q11.23	23	168 kDa	Recognition	Initiation of TCNER, promote complex formation at DNA repair sites
ERCC8 (CSA)	5q12.1	13	44 kDa	Recognition	Initiation of TCNER, interacts with ERCC6
XPA	9q22.33	10	31 kDa	Recognition	Initiates repair by binding to DNA damaged sites
XPC	3p25.1	18	106 kDa	Recognition	Specifically participates in GGNER, XPC complex preferentially binds damaged DNA
DDB1	11q12.2	27	127 kDa	Recognition	Recognize UV-induced DNA damage by forming a complex with DDB2
DDB2	11p11.2	10	48 kDa	Recognition	Recognize UV-induced DNA damage by forming a complex with DDB1