The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates Colorectal Carcinogenesis and Prognosis

Table 3

Association of NER pathway mRNA expression with clinicopathological parameters of CRC.

Cancer type	Gene	Expression	TNM			T			N			M
			III-IV	I-II		T3/T4	TI/T2		Presence	Absence		Presence	Absence
Colon cancer	ERCC3	High	101	130		179	58		96	141		39	173
		Low	97	137	0.621	202	36	0.011	97	142	0.986	27	176	0.156
	ERCC5	High	107	121		199	38		106	132		41	160
		Low	91	146	0.063	182	56	0.040	87	151	0.076	25	189	0.015
	DDB2	High	85	150		190	47		84	154		24	186
		Low	113	117	0.005	191	47	0.982	109	129	0.020	42	163	0.012
Rectal cancer	ERCC2	High	37	42		58	25		38	44		13	65
		Low	38	39	0.753	69	12	0.019	40	40	0.641	10	61	0.663
	XPA	High	44	33		69	12		47	33		9	63
		Low	31	48	0.025	58	25	0.019	31	51	0.008	14	63	0.337