The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates Colorectal Carcinogenesis and Prognosis

Table 4

Prognostic role of NER pathway mRNA expression in CRC.

Gene	Subgroup	Colon cancer				Rectal cancer
		Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
		HR (95% CI)		Adjusted HR (95% CI)		HR (95% CI)		Adjusted HR (95% CI)
ERCC1		1.30 (0.88–1.93)	0.192	1.27 (0.84–1.90)	0.256	1.23 (0.57–2.65)	0.606	0.97 (0.40–2.34)	0.951
ERCC2		1.35 (0.91–2.00)	0.142	1.53 (1.01–2.31)	0.043	1.26 (0.58–2.73)	0.559	2.48 (0.90–6.82)	0.078
	Male			1.84 (1.04–3.26)	0.037
	Female			1.22 (0.66–2.24)	0.532
ERCC3		1.16 (0.79–1.71)	0.459	0.89 (0.60–1.34)	0.587	1.07 (0.49–2.35)	0.870	1.49 (0.59–3.77)	0.404
ERCC4		0.76 (0.51–1.12)	0.166	0.74 (0.49–1.11)	0.148	0.52 (0.23–1.14)	0.101	0.70 (0.28–1.76)	0.452
	Male			0.54 (0.30–0.96)	0.035
	Female			1.15 (0.63–2.09)	0.654
ERCC5		1.16 (0.79–1.72)	0.449	0.95 (0.63–1.42)	0.784	0.82 (0.38–1.78)	0.613	0.64 (0.26–1.56)	0.328
ERCC6		1.11 (0.76–1.64)	0.592	1.24 (0.83–1.84)	0.302	1.38 (0.63–3.02)	0.415	1.16 (0.48–2.80)	0.745
ERCC8		0.95 (0.64–1.39)	0.780	1.01 (0.67–1.52)	0.964	0.95 (0.44–2.07)	0.905	1.75 (0.71–4.34)	0.224
XPA		1.19 (0.80–1.77)	0.398	1.13 (0.75–1.71)	0.552	1.24 (0.56–2.74)	0.591	0.98 (0.36–2.68)	0.971
XPC		0.85 (0.58–1.25)	0.407	0.75 (0.50–1.12)	0.159	0.40 (0.18–0.89)	0.026	0.55 (0.21–1.42)	0.214
	Male					0.26 (0.08–0.88)	0.030
	Female					0.61 (0.20–1.87)	0.385
DDB1		0.73 (0.50–1.08)	0.118	0.87 (0.58–1.30)	0.488	0.62 (0.28–1.39)	0.242	0.90 (0.37–2.19)	0.811
DDB2		1.03 (0.70–1.52)	0.882	1.27 (0.84–1.92)	0.262	1.32 (0.61–2.86)	0.482	1.24 (0.51–2.99)	0.636