An Overview of Meta-Analyses of Endovascular Bridging Therapies for Acute Ischemic Stroke

Table 4

Efficacy of secondary outcomes from the pooled data.

	ET + IVT versus IVT						IAT versus IVT		EBT versus IVT
Primary studies of meta-analysis	Singh et al. 2013	Balami et al. 2015	Elgendy et al. 2015	Badhiwala et al. 2015	Goyal et al. 2016	Campbell et al. 2016	Lee et al. 2010	Fields et al. 2011	Fargen et al. 2015
Mortality
N1/T1	127/707	206/1312	15.9%	218/1312	97/633	48/401	46/224	40/201	203/1071
N2/T2	84/490	194/1106	17.9%	201/1106	122/646	63/386	41/171	24/130	156/832
OR; 95% CI	0.98; (0.76–1.25)	0.84; (0.64–1.05)	0.82; (0.67–1.02)	0.87; (0.68–1.12)	0.77; (0.54–1.10)	0.69; (0.43–1.1)	0.83; (0.48–1.39)	0.84; (0.47–1.52)	0.96; (0.76–1.22)
value	>0.05	0.12	0.08	0.27	0.16	0.12	0.46	0.57	0.73
sICH rate
N1/T1	42/707	66/1312	5.1%	70/1312	28/633	10/401	20/224	20/201
N2/T2	30/490	53/1106	5.0%	53/1106	28/646	11/386	4/171	3/130
OR; 95% CI	0.99; (0.62–1.58)	1.03; (0.71–1.49)	1.02; (0.69–1.52)	1.12; (0.77–1.63)	1.07; (0.62–1.83)	0.87; (0.36–2.1)	2.87; (1.21–6.83)	4.58; (1.31–15.97)
value	>0.05	0.88	0.92	0.56	0.8	0.76	0.02	0.02
Revascularization
OR; 95% CI			3.09; (2.46–3.89)	6.49; (4.79–8.79)
value			0.0001	<0.01

EBT: endovascular bridging therapies; ET: endovascular thrombectomy; IAT: intra-arterial pharmacologic thrombolysis; IVT: intravenous rt-PA; mRS: modified Rankin scale; OR: odds ratio; and 95% CI: 95% confidence interval.