BioMed Research International / 2018 / Article / Fig 1

Review Article

Onco-Multi-OMICS Approach: A New Frontier in Cancer Research

Figure 1

Pyramid of complexity. The pyramid represents the flow of information from genome (top) to transcriptome (middle), to proteome (bottom). The complexity increases from genome to proteome (indicated by down arrow). The complexity of transcriptome is largely mediated by temporal dynamics and alternative splicing. In contrast, spatiotemporal dynamics and posttranslational modifications (PTMs) are mainly responsible for high proteome complexity. Examples of PTMs include phosphorylation (P) and acetylation (Ac).

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