Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review

Table 3

Drug-related risk factor of osteonecrosis of the jaw in the cancer population according to Campisi et al. 2011 [11].

Risk Factor	Strenght
Zoledronate vs Other Bisphosphonate	+++
Intravenouse vs Oral Bisphosponate	++
Bisphosphonate cumulative dose	+++
Bisphosphonate duration of treatment	+++
Anti-angiogenic drugs	++
Denosumab	++
Chemotherapy	-/+
Thalilomide	+/-