Review Article

Microsurgical Reconstruction of the Jaws Using Vascularised Free Flap Technique in Patients with Medication-Related Osteonecrosis: A Systematic Review

Table 7

Preoperative pharmacological analysis: type of drugs, indication for drug therapy, and time of drug exposure. ZOL: zoledronate; ALD: alendronate; PMT: pamidronate; COL: clodronate; DZM: denosumab; IBA: ibandronate; ETI: etidronate; mth: months; RSD: risedronate; NR: not reported.

StudyType of drugIndication for drug therapytime of drug exposure

Engroff and Kim (2007) [28]PMT (x 1 case)
ZOL (x 1 case)
Brest Cancer (x 2 cases)NR

Ferrari et al. (2008) [29]PMT + ZOLMultiple Myeloma21 mth (PMT)
3 mth (ZOL) discontinue therapy

Mücke et al. (2009) [30]ZOL (x 2 cases)Brest cancer (x 1 case);
Multiple Myeloma (x 1 case)
50mth (ZOL)
36 mth (ZOL)

Nocini et al. (2009) [31]PMT and ZOL (x 5 cases)
ZOL (x 2 cases)
Brest Cancer (x 5 cases);
Prostate Cancer (x 1 case);
Myeloid leukaemia and Osteoporosis (x 1 case)
NR

Seth et al. (2010) [32]ZOL (x 6 cases)
ALD (x 2 cases)
IBA (x 2 cases)
ETI (x 1 case)
Brest Cancer (x 5 cases);
Prostate Cancer (x 2 cases);
Multiple Myeloma (x 2 cases);
Osteoporosis (x 2 cases)
NR

Bedogni et al. (2011) [33]NRNRNR

Pautke et al. (2011) [34]ZOLProstate Cancer40 mth

Bittner et al. (2012) [35]ZOL and PMTPain syndrome12 mth (ZOL)
3 mth (PMT)

Ghazali et al. (2013) [36]ALDOsteoporosis84 mth (ALD)

Hanasono et al. (2013) [37]ZOL (x 9 cases)
PMT (x 2 cases)
Multiple Myeloma (x 5 cases);
Breast Cancer (x 2 cases);
Prostate Cancer (x 2 cases);
Osteoporosis (x 2 cases)
NR

Horta et al. (2014) [38]ZOLLung Cancer36 mth (ZOL)

Spinelli et al. (2014) [39]ZOL (x 3 cases)
PMT (x 3 cases)
ZOL and PMT (x 2 cases)
Multiple Myeloma (x 4 cases);
Brest Cancer (x 3 cases);
Prostate Cancer (x 1 case)
1 x 27 mth (ZOL)
1 x 21 mth (ZOL)
1 x 35 mth (ZOL
1 x 22 mth (PMT)
1 x 30 mth (PMT)
1 x 19 mth (PMT
1 x 25 mth (ZOL and PMT)
1 x 17 mth (ZOL and PMT)

Vercruysse et al. (2014) [25]1 x ZOL
1 x ZOL + PMT
1 x ZOL + CLO
Multiple Myeloma (x 2 case);
Brest Cancer (x 1 case)
1 x 22mth (ZOL)
1x 12 mth (PMT) + 26 mth (ZOL)
1x 96 mth (CLO) + 29mth (ZOL)

Kim et al. (2015) [40]ALD (x 2)
ALD + RSD + PMT (x 1)
ZOL + PMT (x 1)
Osteoporosis (x 3)
Multiple Myeloma (x 1)
1 x 48 mth (ALD)
1 x 120 mth (ALD
1 x 24 mth (ALD + RSD +PMT)
1 x 30mth (ZOL +PMT)

Mücke et al. (2016) [41]NRNRNR

Neto et al. (2016) [26]ZOLLung Cancer36 mth (ZOL)

Sotsuka et al (2016) [42]ZOLBrest Cancer59 mth (ZOL)

Caldroney et al. (2017) [43]7 x ZOL
2 x ALD
1 x ZOL + DZM
1 x PMT + DZM
Brest Cancer (x 4 cases)
Osteoporosi (x 3 cases)
Multiple Myeloma (x 3 cases)
Prostate Cancer (x 1 case)
NR