Research Article

Exploring the Pathological Mechanism of Bladder Cancer Based on Tumor Mutational Burden Analysis

Figure 1

Visualization of somatic disorders from bladder cancer. (a) Cohort summary plot displaying distribution of variants according to variant classification, type, and SNV class. Bottom part (from left to right) indicates mutation load for each sample, variant classification type. A stacked barplot shows top ten mutated genes. (b) Mutually exclusive and cooccurring gene pairs in bladder cancer displayed as a triangular matrix. Green indicates tendency toward cooccurrence, whereas pink indicates tendency toward exclusiveness. (c) Waterfall plot displaying the somatic landscape of BLCA cohort. Genes are ordered by their mutation frequency, and the type of mutation is shown in the comment bar (bottom).

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