(a) Sensitization to food allergens
(b) Sensitization to food allergens
(c) Sensitization to food allergens
(d) Sensitization to aeroallergens

Figure 3: Receiver operating characteristic (ROC) curves and area under the curve (AUC) obtained from different logistic regression models implemented through GEE to predict the development of sensitization to allergens. Left panel: (a) H3 acetylation (H3ac) at the IFNG promoter versus sensitization to food allergens in boys, (b) H4 acetylation (H4ac) at the HDAC4 promoter in girls versus sensitization to food allergens in girls, (c) H3 acetylation (H3ac) at the SH2B3 locus versus sensitization to food allergens in nonanthroposophic children (non-anth), and (d) H4 acetylation (H4ac) at the HDAC4 promoter versus sensitization to aeroallergens in girls. Right panel: (a-d), analogous prediction obtained when the GEE logistic model is further adjusted for the other histone acetylation variables showing significant associations with sensitization to allergens, as indicated (see also Figures 1 and 2).