Effect of Cilostazol on the Pharmacokinetics of Simvastatin in Healthy Subjects
Table 3
Serum lipid profiles following a single dose of simvastatin alone on days 1 and 2 and in combination with cilostazol on days 6 and 7.
Variable
Simvastatin
Cilostazol + Simvastatin
Day 1
Day 2
Day 6
Day 7
(n = 17)
(n = 17)
(n = 17)
(n = 17)
Total cholesterol (mg/dL)
164.5 ± 29.5
164.8 ± 29.7
159.0 ± 27.7
157.8 ± 28.8
p-value
-
1.0000
0.6053
0.5713
Triglyceride (mg/dL)
108.5 ± 41.8
99.6 ± 25.7
82.0 ± 19.6
78.2 ± 19.9
p-value
-
0.8124
0.0200
0.0126
LDL-cholesterol (mg/dL)
97.9 ± 27.9
99.4 ± 27.7
92.1 ± 25.9
92.8 ± 27.7
p-value
-
1.0000
0.4967
0.7611
HDL-cholesterol (mg/dL)
50.9 ± 12.5
49.6 ± 13.2
53.0 ± 12.0
53.5 ± 13.9
p-value
-
1.0000
0.7115
0.6426
Data are presented as arithmetic mean ± standard deviation. p-value of comparison with Day 1 using a mixed effects model with the Bonferroni adjustment.
