Bromodomain and Extraterminal (BET) Protein Inhibition Restores Redox Balance and Inhibits Myofibroblast Activation

Table 2

NOX4 and SOD2 gene expression data extracted from microarray analysis.

Gene	Control; (n=10)	SSc-ILD; (n=8)	Fold change	p value	IPF; (n=3)	Fold change	p value
NOX4	12.3	206.6	16.9	0.012	323.6	26.4	0.016
SOD2	2180.4	311.0	-7.0	<1x10^−6	29.8	-73.2	<1x10^−6

Basal serum-free gene expression in non-ILD control, SSc-ILD, and IPF lung fibroblasts was determined by Affymetrix microarray analysis [27]. Mean expression levels are given in Affymetrix units. Fold changes for SSc-ILD and IPF fibroblasts, and p values adjusted for multiple comparisons, are relative to the expression levels in non-ILD control cells.