Insulin Resistance and Cardiovascular Risks in Different Groups of Hemodialysis Patients: A Multicenter Study
Table 3
Odd ratios of having nontraditional cardiovascular risks among hemodialysis patients with insulin resistance.
Anemia
Low Ca
High Ca
Low PO4
High PO4
High CaxPO4
High iPTH
High Hcy
High CRP
Low Alb
Hyperkalemia
OR (95%CI)
OR (95%CI)
OR (95%CI)
OR (95%CI)
OR (95%CI)
OR (95%CI)
OR (95%CI)
OR (95%CI)
OR (95%CI)
OR (95%CI)
OR (95%CI)
Normal weight
Model 1
1.17 (0.69, 1.99)
0.99 (0.36, 2.72)
0.68 (0.38, 1.21)
1.86 (0.61, 5.62)
0.52 (0.29, 0.93)
0.47 (0.24, 0.93)
0.77 (0.45, 1.30)
1.08 (0.52, 2.27)
2.19 (1.18, 4.03)
9.25 (2.69, 31.79)
0.39 (0.22, 0.68)
Model 2
0.98 (0.55, 1.72)
1.25 (0.42, 3.69)
0.72 (0.39, 1.32)
1.71 (0.54, 5.40)
0.52 (0.28, 0.96)
0.51 (0.25, 1.03)
0.83 (0.48, 1.44)
0.98 (0.45, 2.12)
2.21 (1.16, 4.22)
8.31 (2.35, 29.37)
0.39 (0.22, 0.70)
Overweight/Obese
Model 1
0.84 (0.45, 1.59)
4.27 (1.24, 14.69)
1.86 (0.95, 3.65)
3.72 (0.92, 15.08)
1.63 (0.84, 3.15)
1.26 (0.65, 2.45)
1.39 (0.74, 2.65)
0.96 (0.39, 2.36)
0.80 (0.41, 1.55)
0.83 (0.32, 2.13)
0.71 (0.36, 1.38)
Model 2
0.82 (0.41, 1.62)
3.00 (0.80, 11.20)
1.94 (0.96, 3.90)
3.54 (0.84, 14.96)
1.69 (0.82, 3.51)
1.23 (0.60, 2.50)
1.36 (0.68, 2.71)
0.98 (0.38, 2.53)
1.04 (0.51, 2.10)
0.68 (0.25, 1.82)
0.87 (0.42, 1.79)
Non-diabetes
Model 1
1.04 (0.62, 1.75)
1.55 (0.57, 4.24)
0.87 (0.50, 1.52)
2.74 (0.84, 8.93)
0.65 (0.37, 1.13)
0.83 (0.46, 1.51)
0.97 (0.58, 1.62)
1.07 (0.52, 2.20)
1.58 (0.87, 2.86)
6.03 (1.71, 21.32)
0.32 (0.18, 0.56)
Model 2
1.04 (0.60, 1.82)
1.44 (0.49, 4.20)
0.75 (0.42, 1.36)
2.62 (0.78, 8.85)
0.51 (0.27, 0.95)
0.62 (0.32, 1.22)
0.86 (0.50, 1.48)
1.01 (0.47, 2.16)
1.58 (0.85, 2.95)
6.59 (1.81, 23.95)
0.31 (0.17, 0.57)
Diabetes
Model 1
1.18 (0.62, 2.25)
2.38 (0.74, 7.71)
1.79 (0.90, 3.55)
2.24 (0.61, 8.22)
1.73 (0.87, 3.42)
1.00 (0.49, 2.06)
1.50 (0.77, 2.93)
0.63 (0.24, 1.64)
1.26 (0.65, 2.44)
2.31 (0.96, 5.52)
1.06 (0.54, 2.11)
Model 2
1.12 (0.56, 2.21)
2.11 (0.55, 8.15)
1.59 (0.77, 3.28)
2.41 (0.62, 9.40)
1.70 (0.82, 3.49)
0.97 (0.45, 2.06)
1.71 (0.82, 3.54)
0.74 (0.27, 2.04)
1.22 (0.60, 2.48)
2.05 (0.80, 5.26)
1.18 (0.57, 2.46)
Overall
Model 1
1.09 (0.73, 1.64)
1.53 (0.72, 3.25)
1.03 (0.67, 1.59)
2.53 (1.06, 6.02)
1.01 (0.66, 1.54)
0.95 (0.60, 1.50)
0.88 (0.59, 1.32)
1.24 (0.70, 2.19)
1.42 (0.91, 2.21)
3.23 (1.62, 6.45)
0.51 (0.33, 0.78)
Model 2
1.06 (0.69, 1.63)
1.38 (0.61, 3.15)
0.95 (0.60, 1.49)
2.35 (0.97, 5.71)
0.99 (0.62, 1.57)
0.89 (0.54, 1.46)
0.93 (0.61, 1.43)
1.27 (0.70, 2.30)
1.30 (0.82, 2.06)
3.07 (1.51, 6.23)
0.56 (0.36, 0.88)
Significant level at p < 0.05, p < 0.01, p < 0.001. Model 1: elevated HOMA-IR and traditional CVD risk factors. Model 2: adjusted for age, gender, hemodialysis vintage, Charlson comorbidity index, physical activity, and body mass index (for nondiabetes, diabetes, and overall sample). Ca, serum calcium; PO4, serum phosphorus; CaxPO4, calcium phosphorus product; iPTH, intact parathyroid hormone; hs-CRP, high sensitive C-reactive protein; Alb, serum albumin.
