BioMed Research International / 2019 / Article / Fig 4

Research Article

A 6-Gene Risk Signature Predicts Survival of Glioblastoma Multiforme

Figure 4

Functional annotation of signature genes. (a) Volcano plot of expressed genes. Orange and blue dots indicate upregulated and downregulated DEGs, respectively. Black dots indicate genes with no significant changes in expression level. The horizontal red dash line indicates where false discovery rate (FDR) = 0.05 and the vertical red dash lines indicate where = 0.263. (b) Heatmap showing the expression levels of DEGs. Downregulated and unregulated genes are shown in green and red, respectively. (c) Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) terms enriched by DEGs between high and low risk group. Pathway and functional terms (vertical axis) are plotted against genes numbers (horizontal axis). The values of –lg(FDR) are in proportion to the sizes of dots.


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