|
| Study [Ref.] | Study design | Patients | CAP aetiologies | Protein combination and signature |
|
Engelmann et al., 2015
[36] | prospective multicenter cohort study | 553 children | viral infections (n = 133)
bacterial infections (n = 48)
uninfected controls (n = 133) | MxA + CRP |
|
Sambursky et al., 2015
[37] | prospective, single center, blinded, observational clinical trial | 54 adults | viral infections:
influenza A, influenza B, parainfluenza 2, parainfluenza 3
(n = 10)
bacterial infections (n = 20)
uninfected controls (n = 24) | MxA + CRP |
|
Zhu et al., 2015
[38] | prospective cohort study | 96 children | viral infections:
Influenza virus,
RSV,
Human bocavirus,
Parainfluenza virus,
Adenovirus,
Coronavirus,
Influenza virus + RSV
(n = 51)
bacterial infections (n = 45) | CRP + CD35 + CD64,
CRP + CD35,
CRP + CD64 |
|
Valim et al., 2016
[39] | prospective cohort study | 80 children | virus (n = 30)
the most common pathogen were rhinovirus,
RSV, and adenovirus
malaria (n = 27)
bacteria (n = 23) | haptoglobin +TNFR-2+ TIMP-1,
haptoglobin + IL-10+ TIMP-1,
haptoglobin + IL-10, CK-MB |
|
Oved et al, 2015
[41] | prospective cohort study
Curiosity | 765 children and adults | Training set:
viral infections:
(n = 167),
the most common pathogen were
Rhinovirus,
Adenovirus,
Parainfluenza,
Influenza A,
and RSV
bacterial infections (n = 160)
uninfected controls (n = 56)
Validation set:
viral infections:
(n = 167),
the most common pathogen were
Rhinovirus,
Adenovirus,
Parainfluenza,
Influenza A,
and RSV
bacterial infections (n = 159)
uninfected controls (n = 56) | CRP + TRAIL + IP-10 |
|
Eden et al., 2016
[42] | sub-study of prospective cohort study Curiosity | 155
children and adults | viral infections:
(n = 128)
bacterial or mixed infections (n = 27) | CRP + TRAIL + IP-10 |
|
Srugo et al., 2017
[43] | prospective double-blind, multicenter study | 361
children | unknown
(n = 54)
viral infections:
(n = 239)
bacterial infections (n = 68) | CRP + TRAIL + IP-10 |
|
van Houten et al., 2017
[44] | prospective, double-blind, international, multicentre study OPPORTUNITY | 577 children | unknown
(n = 71)
viral infections:
(n = 435)),
the most common pathogen were
Rhinovirus and RSV
bacterial infections (n = 71) | CRP + TRAIL + IP-10 |
|
Ashkenazi-Hoffnung et al., 2018
[45] | sub-study of prospective cohort study Curiosity | 314
children and adults | viral infections:
(n = 175)
bacterial infections (n = 139) | CRP + TRAIL + IP-10 |
|
