Research Article

Effect of Lonicera caerulea var. emphyllocalyx Extracts on Murine Streptococcus pyogenes Infection by Modulating Immune System

Figure 2

Administration of LCEEs increased the survival rate of S. pyogenes-infected murine models. Three-week-old ICR mice were gavaged with LCEEs ((a) fruits, (b) stems, and (c) leaves) for 4 consecutive days (day −1, 0, 1, and 2) and inoculated with 1×108 CFU of S. pyogenes 1529 at day 0. Mortality was monitored for 7 days. Survival data were assessed by Kaplan–Meier survival analysis and tested for significance using the log-rank test (n = 6). p< 0.01 by Kaplan–Meier survival analysis.