AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway
AVE 0991 inhibited the expression of NLRP3, caspase-1 and IL-1β by downregulating NOX4 in vivo. (a) Protein expression levels in the liver tissue were analysed by western blotting. The quantified relative protein expression is shown in the graph (right). P < 0.05 compared with the sham group. #P< 0.05 compared with the heat 9 h group. (b) Immunohistochemical staining for NOX4, NLRP3, caspase-1 and IL-1β protein expression levels. The comparative fold change of density/area is shown in the graph (bottom). Heat group: 9 h after heatstroke onset. The data are presented as the mean ± SD. All of the assays were performed in triplicate.P < 0.05 compared with the sham group. #P< 0.05 compared with the heat group.
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