AVE 0991 Attenuates Pyroptosis and Liver Damage after Heatstroke by Inhibiting the ROS-NLRP3 Inflammatory Signalling Pathway

Table 1

Characteristics of heatstroke patients according to liver function.

Parameters	Hepatic; dysfunction; (n= 28, 40.6%)	Non-hepatic dysfunction; (n=41,59.4%)	P value
Ang II (pg/ml)	145.59(44.56-406.98)	39.75(33.32-54.75)	<0.001
Ang-(1-7) (pg/ml)	398.53±257.26	718.59±302.87	<0.001
Ang II/ Ang-(1-7) ratio	0.38(0.12-1.57)	0.07(0.04-0.12)	<0.001
Length of ICU stay (days)	8(2-49)	3(3-5)	<0.001
Organ support (yes/no)	14/14	4/37	-
Death (yes/no)	8/20	0/41	-

Ang II, angiotensin II; Ang-(1-7), angiotensin-(1-7); Organ support: invasive mechanical ventilation, haemopurification or haemodynamic support. Non-normally distributed data are expressed as median (25th percentiles, 75th percentiles) or percentages; “-”, chi-square tests are invalid because of small incidence in the non-hepatic dysfunction group.