Study on the Potential Biomarkers of Maternal Urine Metabolomics for Fetus with Congenital Heart Diseases Based on Modified Gas Chromatograph-Mass Spectrometer

Table 3

Wilcoxon-Mann-Whitney test of 34 potential biomarkers between case group and control group.

NO	Potential biomarkers	VIP	Control group			Case group			Z	P	diagnostic values
			median	Minimum value	Max value	median	Minimum value	Max value
1	1,4-butanediol	3.11	0.04	0.00	1.66	0.08	0.01	1.56	0.762	0.448	—
2	tartaric acid	2.56	2.36	0.00	20.00	7.42	0.00	121.68	1.540	0.126	—
3	4-Hydroxybenzeneacetic acid	2.27	4.20	0.00	33.21	18.07	0.00	137.18	5.777	0.000	6.87
4	5-Trimethylsilyloxy-n-valeric acid	2.24	5.91	0.00	12.01	14.51	0.00	137.18	5.698	0.000	0.48
5	citramalic acid	2.02	6.04	0.00	61.29	2.21	0.00	26.21	-3.080	0.003	3.11
6	2-hydroxyvaleric acid	1.95	0.62	0.00	48.31	1.28	0.00	49.50	0.798	0.426	—
7	aconitic acid	1.87	4.67	0.00	40.00	10.00	0.00	70.00	4.615	0.000	35.01
8	2,4-dihydroxybutyric acid	1.83	0.28	0.00	1.10	2.09	0.00	7.33	4.423	0.000	0.22
9	D-galactose	1.79	2.09	0.00	20.00	3.97	0.00	10.00	2.338	0.021	21.01
10	hippuric acid	1.78	10.00	0.00	30.00	10.00	0.00	30.00	1.375	0.171	—
11	1,4-dihydroxybutyric acid	1.62	2.09	0.00	30.00	11.90	0.00	40.00	1.916	0.058	—
12	α- ketoglutarate	1.60	30.00	0.00	210.00	30.00	0.00	290.00	1.484	0.140	—
13	Ethanamine	1.56	10.00	0.00	30.00	10.00	0.00	30.00	1.879	0.062	—
14	uracil	1.47	0.89	0.00	4.54	0.00	0.00	12.88	3.525	0.001	3.84
15	hydracrylic acid	1.44	0.00	0.00	15.90	6.71	0.00	56.00	3.401	0.001	0.63
16	L- actamic acid	1.37	0.00	0.00	9.25	0.95	0.00	75.66	2.790	0.006	1.14
17	3-hydroxyphenylacetic acid	1.33	31.90	0.00	435.88	74.71	0.00	771.96	2.446	0.016	0.11
18	3-hydroxy butyric acid	1.26	0.00	0.00	4.20	0.04	0.01	11.99	2.805	0.006	0.01
19	pyruvate	1.25	0.00	0.00	0.00	0.00	0.00	51.17	2.975	0.004	0.28
20	stearate	1.23	0.63	0.00	4.11	0.60	0.00	8.17	0.035	0.972	—
21	malonic acid	1.23	0.00	0.00	16.81	12.59	0.00	320.00	2.704	0.008	0.96
22	2,3-dihydroxypropanoic acid	1.22	0.00	0.00	10.00	0.00	0.00	10.00	2.281	0.024	11.01
23	D-galactitol	1.22	0.00	0.00	20.00	2.09	0.00	40.00	2.377	0.020	15.01
24	oxlate	1.21	0.00	0.00	0.06	0.00	0.00	0.77	1.757	0.083	—
25	D- sorbofuranose	1.14	7.31	0.00	40.00	12.09	0.00	70.00	1.134	0.259	—
26	2-keto-l-gluconic	1.14	0.00	0.00	10.00	10.00	0.00	20.00	2.157	0.033	5.01
27	HPHPA	1.12	31.90	0.00	435.88	74.71	0.00	771.96	2.630	0.010	58.81
28	L- sorbofuranose	1.11	1.09	0.00	10.00	2.87	0.00	10.00	0.724	0.470	—
29	L-glycine	1.07	5.59	0.00	33.16	2.55	0.00	18.75	2.605	0.010	0.65
30	uric acid	1.07	0.55	0.00	5.53	1.02	0.00	12.51	2.199	0.030	0.95
31	L-erythrose	1.05	0.00	0.00	30.87	1.25	0.00	41.63	1.448	0.150	—
32	2,3-Hydroxybutanediol	1.03	15.90	0.00	240.00	45.76	0.00	220.00	2.281	0.024	5.01
33	D-fructose	1.02	0.22	0.00	4.55	0.23	0.00	1.74	1.612	0.110	—
34	L-threonine	1.01	30.00	0.00	210.00	30.00	0.00	290.00	1.879	0.062	—

remarks: 3-(3-hydroxyphenyl)-3-hydroxypropionic acid: HPHPA