Research Article

An Approach to Enhance Dissolution Rate of Tamoxifen Citrate

Table 1

The phase solubility of TC PMs complexes in water and phosphate-buffered saline (PBS, pH 6.8, 7.4) at 37°C.

SamplesRatioSolubility mg/ml
Water6.8 pH PBS7.4 pH PBS

Drug-0.479±0.020.392±0.020.319±0.02
TC+PEG 6000 (F1)1:20.834±0.020.719±0.030.862±0.01
TC+β-CD (F2)1:20.846±0.040.913±0.010.915±0.03
TC+PEG6000+β-CD (F3)1:2:20.853±0.030.946±0.050.834±0.01
TC+PEG6000+β-CD (F4)1:2:40.888±0.030.989±0.050.889±0.01
TC+PEG6000+β-CD (F5)1:2:60.987±0.041.324±0.051.156±0.03