Research Article
An Approach to Enhance Dissolution Rate of Tamoxifen Citrate
Table 1
The phase solubility of TC PMs complexes in water and phosphate-buffered saline (PBS, pH 6.8, 7.4) at 37°C.
| Samples | Ratio | Solubility mg/ml | Water | 6.8 pH PBS | 7.4 pH PBS |
| Drug | - | 0.479±0.02 | 0.392±0.02 | 0.319±0.02 | TC+PEG 6000 (F1) | 1:2 | 0.834±0.02 | 0.719±0.03 | 0.862±0.01 | TC+β-CD (F2) | 1:2 | 0.846±0.04 | 0.913±0.01 | 0.915±0.03 | TC+PEG6000+β-CD (F3) | 1:2:2 | 0.853±0.03 | 0.946±0.05 | 0.834±0.01 | TC+PEG6000+β-CD (F4) | 1:2:4 | 0.888±0.03 | 0.989±0.05 | 0.889±0.01 | TC+PEG6000+β-CD (F5) | 1:2:6 | 0.987±0.04 | 1.324±0.05 | 1.156±0.03 |
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