Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model

Table 3

Drug loaded NE formulation composition and physical screening studies.

Formulation code	Surfactant  :  co-surfactant ratio	Oil %	%		Water %	Physical Stability test			Inference
						Heating	Freeze thaw cycle	Centrifugation
F1	4:1	10	32	8	50	✓	✓	✓	Passed
F5		11.94	14.33	3.58	70.15	-	-	-	Failed
F7		11.63	18.61	4.65	65.12	✓	-	-	Failed
F8		11.11	19.445	19.445	50	✓	-	-	Failed
F12		6.67	11.665	11.665	70	✓	-	-	Failed
F14		6.67	16.665	16.665	60	✓	-	-	Failed
F15		5.8	14.495	14.495	65.22	-	-	-	Failed

Composition of drug loaded NE and their physical stability testing, F1 gave a clear and transparent formulation.