Predicting Drug-Disease Associations via Using Gaussian Interaction Profile and Kernel-Based Autoencoder

Table 8

Top-20 drugs predicted by GIPAE to be associated with Alzheimer disease based on Fdatabase.

Index	Drug name	Evidence	Index	Drug name	Evidence
1	Dopamine	Confirmed	11	Ranitidine	Confirmed
2	Methylergonovine	N.A.	12	Nizatidine	N.A.
3	Meperidine	N.A.	13	Nifedipine	Confirmed
4	Gemcitabine	Confirmed	14	Lithium	Confirmed
5	Betamethasone	Confirmed	15	Esomeprazole	N.A.
6	Pioglitazone	Confirmed	16	Ergocalciferol	Confirmed
7	Guanethidine	Confirmed	17	Dihydrocodeine	N.A.
8	Valrubicin	N.A.	18	Amitriptyline	Confirmed
9	Teriparatide	N.A.	19	Almotriptan	Confirmed
10	Rizatriptan	N.A.	20	Adenosine	N.A.