Research Article

The Effects of Once-Weekly Dulaglutide and Insulin Glargine on Glucose Fluctuation in Poorly Oral-Antidiabetic Controlled Patients with Type 2 Diabetes Mellitus

Table 2

Biochemical characteristics.

Dulaglutide group ()Glargine group ()

Fasting blood glucoseBaseline10.26 ± 2.8410.72 ± 2.34−0.4180.68
(mmol/L)52w8.21 ± 1.706.92 ± 1.601.850.077
HbA1c (%)Baseline8.65 ± 1.578.73 ± 0.64−0.1860.854
52w7.16 ± 1.177.40 ± 1.12−0.5070.617
Total amylase (U/L)Baseline69.44 ± 26.8064.78 ± 17.350.4670.645
52w80.44 ± 29.9859.44 ± 13.711.9740.061
Pancreatic enzymesBaseline29.00 ± 7.9128.22 ± 9.850.2160.831
(U/L)52w30.50 (28.25, 37.50)24.00 (20.00, 31.00)−2.2120.026
Lipase (U/L)Baseline43.94 ± 11.6041.44 ± 14.150.4770.638
52w50.50 (38.50, 59.00)37.00 (24.00, 55.50)−1.7280.087
Cholesterol (mmol/L)Baseline4.81 ± 1.044.67 ± 1.050.3240.749
52w4.68 ± 1.104.79 ± 1.35−0.2210.827
HDL-cholesterol (mmol/L)Baseline1.24 ± 0.211.31 ± 0.34−0.6540.52
52w1.21 ± 0.281.13 ± 0.340.6020.553
LDL-cholesterol (mmol/L)Baseline2.82 ± 0.812.54 ± 1.020.7680.45
52w2.68 ± 0.872.27 ± 0.801.1680.255
Triglyceride (mmol/L)Baseline1.64 ± 0.871.97 ± 1.63−0.6550.519
52w1.57 (0.88, 2.45)1.50 (0.92, 5.866)−0.1420.901
Calcitonin (ng/L)Baseline2.24 ± 0.852.57 ± 0.73−0.9540.35
52w2.13 ± 0.532.11 ± 0.330.1030.919
Change0 (0, 0)−0.30 (−0.70, 0)−2.0740.052
White blood count (109/l)Baseline6.36 ± 1.425.84 ± 1.370.8890.383
52w6.54 ± 1.486.19 ± 1.030.6340.532
Haemoglobin (g/L)Baseline149.63  ±  11.77139.89 ± 9.692.1060.046∗
52w147.63 ± 13.57139.33 ± 10.711.5730.129
Haematocrit (g/L)Baseline0.45 ± 0.040.42 ± 0.032.1670.041
52w0.45 ± 0.040.42 ± 0.031.7060.102
Red blood countBaseline4.91 ± 0.354.46 ± 0.502.650.014
(1012/l)52w4.88 ± 0.394.52 ± 0.422.160.041
Platelet count (109/L)Baseline207.63 ± 68.46180.11 ± 40.201.2660.218
52w212.06 ± 59.10195.33 ± 30.660.9310.361
Blood urea nitrogenBaseline5.51 ± 1.345.55 ± 1.17−0.0780.938
(mmol/L)52w5.42 ± 1.195.43 ± 1.68−0.0210.984
Creatinine (μmol/L)Baseline73.50 ± 15.4865.56 ± 12.511.3140.202
52w73.06 ± 16.3466.78 ± 14.230.9650.345
Alanine aminotransferaseBaseline24.25 ± 13.9317.67 ± 3.351.80.089
(U/L)52w21.00 (15.25, 36.50)22.00 (14.50, 35.50)−0.1420.901
Glutamate aminotransferaseBaseline20.38 ± 5.8416.78 ± 4.211.620.119
(U/L)52w21.50 (18.00, 27.00)23.00 (17.50, 25.50)−0.1990.857
MicroalbuminBaseline22.50 (16.00, 52.25)30.00 (11.00, 70.50)−0.0850.944
(mg/L)52w26.00 (9.25, 47.25)41.00 (9.50, 61.50)−0.5380.607
Microalbumin/creatinineBaseline2.70 (1.13, 6.85)3.80 (1.15, 12.45)−0.5660.588
(mg/g)52w3.30 (0.78, 4.55)4.60 (1.25, 6.55)−1.0760.295
Fasting insulin (nmol/L)Baseline8.75 (5.30, 12.68)7.90 (6.00, 14.00)−0.1130.923
Fasting C-peptide (nmol/L)Baseline0.52 ± 0.310.41 ± 0.200.8880.384
HOMA-IR (%)Baseline0.93 ± 0.350.96 ± 0.38−0.1850.855

HOMA-IR: homeostatic model assessment of insulin resistance.