The Effects of Once-Weekly Dulaglutide and Insulin Glargine on Glucose Fluctuation in Poorly Oral-Antidiabetic Controlled Patients with Type 2 Diabetes Mellitus
Table 2
Biochemical characteristics.
Dulaglutide group ()
Glargine group ()
Fasting blood glucose
Baseline
10.26 ± 2.84
10.72 ± 2.34
−0.418
0.68
(mmol/L)
52w
8.21 ± 1.70
6.92 ± 1.60
1.85
0.077
HbA1c (%)
Baseline
8.65 ± 1.57
8.73 ± 0.64
−0.186
0.854
52w
7.16 ± 1.17
7.40 ± 1.12
−0.507
0.617
Total amylase (U/L)
Baseline
69.44 ± 26.80
64.78 ± 17.35
0.467
0.645
52w
80.44 ± 29.98
59.44 ± 13.71
1.974
0.061
Pancreatic enzymes
Baseline
29.00 ± 7.91
28.22 ± 9.85
0.216
0.831
(U/L)
52w
30.50 (28.25, 37.50)
24.00 (20.00, 31.00)
−2.212
0.026
Lipase (U/L)
Baseline
43.94 ± 11.60
41.44 ± 14.15
0.477
0.638
52w
50.50 (38.50, 59.00)
37.00 (24.00, 55.50)
−1.728
0.087
Cholesterol (mmol/L)
Baseline
4.81 ± 1.04
4.67 ± 1.05
0.324
0.749
52w
4.68 ± 1.10
4.79 ± 1.35
−0.221
0.827
HDL-cholesterol (mmol/L)
Baseline
1.24 ± 0.21
1.31 ± 0.34
−0.654
0.52
52w
1.21 ± 0.28
1.13 ± 0.34
0.602
0.553
LDL-cholesterol (mmol/L)
Baseline
2.82 ± 0.81
2.54 ± 1.02
0.768
0.45
52w
2.68 ± 0.87
2.27 ± 0.80
1.168
0.255
Triglyceride (mmol/L)
Baseline
1.64 ± 0.87
1.97 ± 1.63
−0.655
0.519
52w
1.57 (0.88, 2.45)
1.50 (0.92, 5.866)
−0.142
0.901
Calcitonin (ng/L)
Baseline
2.24 ± 0.85
2.57 ± 0.73
−0.954
0.35
52w
2.13 ± 0.53
2.11 ± 0.33
0.103
0.919
Change
0 (0, 0)
−0.30 (−0.70, 0)
−2.074
0.052
White blood count (∗109/l)
Baseline
6.36 ± 1.42
5.84 ± 1.37
0.889
0.383
52w
6.54 ± 1.48
6.19 ± 1.03
0.634
0.532
Haemoglobin (g/L)
Baseline
149.63 ± 11.77
139.89 ± 9.69
2.106
0.046∗
52w
147.63 ± 13.57
139.33 ± 10.71
1.573
0.129
Haematocrit (g/L)
Baseline
0.45 ± 0.04
0.42 ± 0.03
2.167
0.041∗
52w
0.45 ± 0.04
0.42 ± 0.03
1.706
0.102
Red blood count
Baseline
4.91 ± 0.35
4.46 ± 0.50
2.65
0.014 ∗
(∗1012/l)
52w
4.88 ± 0.39
4.52 ± 0.42
2.16
0.041
Platelet count (∗109/L)
Baseline
207.63 ± 68.46
180.11 ± 40.20
1.266
0.218
52w
212.06 ± 59.10
195.33 ± 30.66
0.931
0.361
Blood urea nitrogen
Baseline
5.51 ± 1.34
5.55 ± 1.17
−0.078
0.938
(mmol/L)
52w
5.42 ± 1.19
5.43 ± 1.68
−0.021
0.984
Creatinine (μmol/L)
Baseline
73.50 ± 15.48
65.56 ± 12.51
1.314
0.202
52w
73.06 ± 16.34
66.78 ± 14.23
0.965
0.345
Alanine aminotransferase
Baseline
24.25 ± 13.93
17.67 ± 3.35
1.8
0.089
(U/L)
52w
21.00 (15.25, 36.50)
22.00 (14.50, 35.50)
−0.142
0.901
Glutamate aminotransferase
Baseline
20.38 ± 5.84
16.78 ± 4.21
1.62
0.119
(U/L)
52w
21.50 (18.00, 27.00)
23.00 (17.50, 25.50)
−0.199
0.857
Microalbumin
Baseline
22.50 (16.00, 52.25)
30.00 (11.00, 70.50)
−0.085
0.944
(mg/L)
52w
26.00 (9.25, 47.25)
41.00 (9.50, 61.50)
−0.538
0.607
Microalbumin/creatinine
Baseline
2.70 (1.13, 6.85)
3.80 (1.15, 12.45)
−0.566
0.588
(mg/g)
52w
3.30 (0.78, 4.55)
4.60 (1.25, 6.55)
−1.076
0.295
Fasting insulin (nmol/L)
Baseline
8.75 (5.30, 12.68)
7.90 (6.00, 14.00)
−0.113
0.923
Fasting C-peptide (nmol/L)
Baseline
0.52 ± 0.31
0.41 ± 0.20
0.888
0.384
HOMA-IR (%)
Baseline
0.93 ± 0.35
0.96 ± 0.38
−0.185
0.855
HOMA-IR: homeostatic model assessment of insulin resistance.