Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells

Figure 6

Schematic diagram of the hypothetical mechanism for lovastatin-induced cytotoxicity in GBM cells. Lovastatin treatment initiated autophagy, which might be mediated via suppressing the Akt/mTOR pathway. The fusion of autophagosome and lysosome was blocked by lovastatin. The impaired autophagic flux led to cellular apoptosis and cell death in GBM cells.