Research Article

Identification and Interaction Analysis of Significant Genes and MicroRNAs in Pterygium

Table 2

Functional and pathway enrichment analysis of hub genes.

CategoryTerm/DescriptionCountP value

GOTERM_BP_FATGO:0010243~response to organonitrogen compound121.35E-10
GOTERM_BP_FATGO:1901698~response to nitrogen compound125.18E-10
GOTERM_BP_FATGO:0009725~response to hormone117.24E-09
GOTERM_BP_FATGO:0071495~cellular response to endogenous stimulus121.01E-08
GOTERM_BP_FATGO:0009719~response to endogenous stimulus131.08E-08
GOTERM_CC_FATGO:0005578~proteinaceous extracellular matrix62.39E-05
GOTERM_CC_FATGO:0031012~extracellular matrix62.73E-04
GOTERM_CC_FATGO:0098644~complex of collagen trimers33.21E-04
GOTERM_CC_FATGO:0044420~extracellular matrix component44.15E-04
GOTERM_CC_FATGO:0005667~transcription factor complex45.34E-03
GOTERM_MF_FATGO:0000982~transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding108.82E-11
GOTERM_MF_FATGO:0001228~transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding92.20E-09
GOTERM_MF_FATGO:0001077~transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding87.56E-09
GOTERM_MF_FATGO:0000981~RNA polymerase II transcription factor activity, sequence-specific DNA binding102.85E-08
GOTERM_MF_FATGO:0044212~transcription regulatory region DNA binding93.61E-06
KEGG_PATHWAYhsa04512:ECM-receptor interaction56.38E-05
KEGG_PATHWAYhsa04510:Focal adhesion61.43E-04
KEGG_PATHWAYhsa04151:PI3K-Akt signaling pathway71.69E-04
KEGG_PATHWAYhsa05200:Pathways in cancer62.74E-03
KEGG_PATHWAYhsa04010:MAPK signaling pathway53.64E-03

If there were more than 5 terms enriched in this category, the top 5 terms were selected according to P value.