MiR-21-3p Plays a Crucial Role in Metabolism Alteration of Renal Tubular Epithelial Cells during Sepsis Associated Acute Kidney Injury via AKT/CDK2-FOXO1 Pathway
Figure 6
Effects of miR-21-3p and relative AKT/CDK2-FOXO1 pathway on lipid metabolism, cell cycle arrest, and apoptosis of TECs. (a) Representative images of Oil Red O staining of NRK52E cells with different treatments. (b) Representative results of flow cytometry for apoptosis of NRK52E cells with different treatments. (c) Representative results of flow cytometry for cell cycle arrest of NRK52E cells with different treatments. (d) Quantitative analysis of Oil Red O staining (: P<0.05 vs. Control; #: P<0.05 vs. miR-21-3p mimic group; : P<0.05 vs. miR-21-3p inhibitor group). (e) Quantitative analysis of flow cytometry for apoptosis (: P<0.05 vs. Control; #: P<0.05 vs. miR-21-3p mimic group; : P<0.05 vs. miR-21-3p inhibitor group). (f) Quantitative analysis of flow cytometry for cell cycle arrest (: P<0.05 vs. Control; #: P<0.05 vs. miR-21-3p mimic group; : P<0.05 vs. miR-21-3p inhibitor group).