BioMed Research International / 2019 / Article / Fig 4

Research Article

Delivery of miRNA-29b Using R9-LK15, a Novel Cell-Penetrating Peptide, Promotes Osteogenic Differentiation of Bone Mesenchymal Stem Cells

Figure 4

Effects of R9-LK15/miR-29b nanocomplexes on ALP activity and ECM mineralization. (a) ALP activity in untreated BMSCs (Con) and those treated with miR-29b, Lipo, R9-LK15, Lipo/miR-29b nanocomplexes, and R9-LK15/miR-29b nanocomplexes for 7 days. (b) Alizarin Red S staining in untreated BMSCs (Con) and those treated with miR-29b, Lipo, R9-LK15, Lipo/miR-29b nanocomplexes, and R9-LK15/miR-29b nanocomplexes for 14 days. (c) Quantification of ALP activity. (d) Quantification of Alizarin Red S staining. Scale bar: 500 μm. < 0.01.

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