Table 2: GO and KEGG pathway enrichment analysis of DEGs in HepG2 cells treated with emodin. (Top 5) P<0.05 was considered statistically significant.

CategoryTermCountP-Value

Upregulated
GOTERM_BPGO:0070370~cellular heat acclimation33.01E-04
GO:0043065~positive regulation of apoptotic process103.04E-04
GO:0032496~response to lipopolysaccharide70.0011565
GO:0090084~negative regulation of inclusion body assembly30.0021952
GO:2001240~negative regulation of extrinsic apoptotic signaling pathway in absence of ligand40.0023164
GOTERM_CCGO:0005576~extracellular region230.0032977
GO:0030016~myofibril30.0179025
GO:0005615~extracellular space180.0200543
GOTERM_MFGO:0042623~ATPase activity, coupled30.0031569
GO:0004252~serine-type endopeptidase activity70.0097873
GO:0008236~serine-type peptidase activity40.0102052
GO:0004947~bradykinin receptor activity20.0141671
GO:0019904~protein domain specific binding60.0164848
KEGG_PATHWAYhsa04010:MAPK signaling pathway102.68E-04
hsa05323:Rheumatoid arthritis50.0066631
hsa04915:Estrogen signaling pathway50.0100336
hsa05134:Legionellosis40.010905
hsa00980:Metabolism of xenobiotics by cytochrome P45040.0252724
Downregulated
GOTERM_BPGO:0010951~negative regulation of endopeptidase activity233.10E-10
GO:0030198~extracellular matrix organization251.58E-07
GO:0007156~homophilic cell adhesion via plasma membrane adhesion molecules219.99E-07
GO:0042060~wound healing145.01E-06
GO:0042730~fibrinolysis85.57E-06
GOTERM_CCGO:0005615~extracellular space1148.37E-18
GO:0005576~extracellular region1245.51E-16
GO:0005578~proteinaceous extracellular matrix351.88E-10
GO:0016021~integral component of membrane2612.10E-10
GO:0005887~integral component of plasma membrane962.35E-09
GOTERM_MFGO:0005509~calcium ion binding638.97E-11
GO:0004867~serine-type endopeptidase inhibitor activity201.22E-09
GO:0005201~extracellular matrix structural constituent122.27E-05
GO:0005198~structural molecule activity237.88E-05
GO:0001530~lipopolysaccharide binding79.18E-05
KEGG_PATHWAYhsa04610:Complement and coagulation cascades182.02E-10
hsa05146:Amoebiasis165.35E-06
hsa04512:ECM-receptor interaction136.15E-05
hsa04974:Protein digestion and absorption136.90E-05
hsa04611:Platelet activation148.04E-04