Anticancer Effects of Emodin on HepG2 Cell: Evidence from Bioinformatic Analysis

Table 3

GO and KEGG pathway enrichment analysis of DEGs in the module. FDR<0.05 was considered statistically significant.

Category	Term	Count	FDR
GOTERM_BP	GO:0007204~positive regulation of cytosolic calcium ion concentration	10	2.54E-10
	GO:0007186~G-protein coupled receptor signaling pathway	15	5.11E-09
	GO:0007193~adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	6	9.72E-06
	GO:0007218~neuropeptide signaling pathway	6	4.76E-04
	GO:0006954~inflammatory response	7	0.0216325
GOTERM_CC	GO:0005887~integral component of plasma membrane	13	9.27E-05
	GO:0005886~plasma membrane	19	2.11E-04
GOTERM_MF	GO:0042923~neuropeptide binding	4	0.0035638
	GO:0004930~G-protein coupled receptor activity	8	0.0619499
KEGG_PATHWAY	hsa04080:Neuroactive ligand-receptor interaction	10	1.78E-05

GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; DEGs, differentially expressed genes; FDR, false discovery rate