Anticancer Effects of Emodin on HepG2 Cell: Evidence from Bioinformatic Analysis

Table 5

Function roles of 5 genes in cancer.

Gene	Expression in cancer	Function in cancer	Ref
C5	Upregulated in HCC	Highly associated with the progression of AFP(-) HBV-related HCC.	[17]
SSTR5	Upregulated in HCC	Regulate intracellular signaling pathways, such as MAPK pathways; constitute a molecular basis for the treatment of HCC with somatostatin analogues.	[2, 32]
LPAR6	Upregulated in HCC	Maintain the proliferation capacity and the tumorigenic phenotype of HCC through the transcriptional activation of protooncogene Pim-3.	[33]
P2RY4	Upregulated in colonic cancer	The function is based on the effect of extracellular nucleotides on apoptosis or cell proliferation in HCT8 and Caco-2 cells.	[7]
GPR68	Upregulated in PDAC and ovarian cancer	Stimulates PDAC proliferation; inhibits ovarian cancer cell proliferation and migration, but enhances the cell adhesion to the extracellular matrix	[34, 35]