BioMed Research International / 2019 / Article / Tab 5

Research Article

Anticancer Effects of Emodin on HepG2 Cell: Evidence from Bioinformatic Analysis

Table 5

Function roles of 5 genes in cancer.

GeneExpression in cancerFunction in cancerRef

C5Upregulated in HCCHighly associated with the progression of AFP(-) HBV-related HCC.[17]
SSTR5Upregulated in HCCRegulate intracellular signaling pathways, such as MAPK pathways; constitute a molecular basis for the treatment of HCC with somatostatin analogues.[2, 32]
LPAR6Upregulated in HCCMaintain the proliferation capacity and the tumorigenic phenotype of HCC through the transcriptional activation of protooncogene Pim-3.[33]
P2RY4Upregulated in colonic cancerThe function is based on the effect of extracellular nucleotides on apoptosis or cell proliferation in HCT8 and Caco-2 cells.[7]
GPR68Upregulated in PDAC and ovarian cancerStimulates PDAC proliferation;
inhibits ovarian cancer cell proliferation and migration, but enhances the cell adhesion to the extracellular matrix
[34, 35]

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.