Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload

<p><i>Astragaloside IV could reduce apoptosis of Lo2 cells induced by iron overload</i>. (a) Flow cytometry (Annexin V + PI) assay was used to detect the early apoptosis of different treatments in Lo2 cells. (b) The proportion of apoptosis was calculated. The control group was given 1 <svg height="8.77704pt" id="M8" style="vertical-align:-0.4347391pt" version="1.1" viewbox="-0.0498162 -8.3423 13.9574 8.77704" width="13.9574pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M586 629L554 652L152 -9L183 -32L586 629ZM192 635C92 635 49 537 49 457C49 380 92 281 191 281C291 281 334 380 334 458C334 537 291 635 192 635ZM192 606C254 606 261 507 261 458C261 412 254 309 193 309C134 309 122 410 122 459C122 509 132 606 192 606ZM554 343C453 343 410 244 410 165C410 87 453 -12 553 -12C652 -12 695 87 695 165C695 244 652 343 554 343ZM876 343C777 343 733 244 733 165C733 87 777 -12 875 -12C975 -12 1018 87 1018 165C1018 244 975 343 876 343ZM553 314C614 314 622 214 622 165C622 119 614 17 554 17C493 17 483 117 483 166C483 216 493 314 553 314ZM875 314C937 314 945 214 945 165C945 119 937 17 876 17C816 17 806 117 806 166C806 216 816 314 875 314Z"></path></g></svg> DMSO, and the model group was given Fe alone. The treatment group was given different concentrations of Astragaloside IV followed with the 60<i>μ</i>M Fe. [###, p&lt;0.001, VS Control; <span class="nowrap"><svg height="6.01072pt" id="M9" style="vertical-align:-0.04980993pt" version="1.1" viewbox="-0.0498162 -5.96091 28.8895 6.01072" width="28.8895pt" xmlns="http://www.w3.org/2000/svg"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 255C215 229 188 220 136 212C125 194 117 171 117 153C132 144 157 139 178 140C211 181 232 200 280 231C277 174 271 146 252 97C262 78 278 59 294 51C309 59 326 78 336 97C317 146 311 174 308 231C356 200 377 181 410 140C431 139 456 143 471 153Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.536,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 255C215 229 188 220 136 212C125 194 117 171 117 153C132 144 157 139 178 140C211 181 232 200 280 231C277 174 271 146 252 97C262 78 278 59 294 51C309 59 326 78 336 97C317 146 311 174 308 231C356 200 377 181 410 140C431 139 456 143 471 153Z"></path></g><g transform="matrix(.013,0,0,-0.013,21.073,0)"><path d="M471 153C471 170 463 194 452 212C400 220 373 229 322 255C373 281 400 290 452 298C463 316 471 339 471 357C456 366 431 371 410 370C377 329 356 310 308 279C311 336 317 364 336 413C326 432 310 451 294 459C279 451 262 432 252 413C271 364 277 336 280 279C232 310 211 329 178 370C157 371 132 367 117 357C117 340 125 316 136 298C188 290 215 281 266 255C215 229 188 220 136 212C125 194 117 171 117 153C132 144 157 139 178 140C211 181 232 200 280 231C277 174 271 146 252 97C262 78 278 59 294 51C309 59 326 78 336 97C317 146 311 174 308 231C356 200 377 181 410 140C431 139 456 143 471 153Z"></path></g></svg>,</span> p&lt;0.001, VS 60Fe].</p>

BioMed Research International

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Figure 2

Figure 2: Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload 