BioMed Research International / 2019 / Article / Fig 4

Research Article

Zebrafish Xenograft Model of Human Lung Cancer for Evaluating Osimertinib Resistance

Figure 4

Osimertinib inhibits the growth of zebrafish xenografts produced by lung cancer cells. Zebrafish are labeled as fli-eGFP; the tumor cells were labeled with red fluorescence. (a) H1975 xenograft zebrafish treated with Osimertinib at 24 hpf and observed at 3 dpt. (b) Quantitative analysis of the H1975 cells proliferation with/without Osimertinib treatment at 3 dpt. (c) H1975-OR xenograft zebrafish treated with Osimertinib at 24 hpf and observed at 3 dpt. (d) Quantitative analysis of the H1975-OR cells proliferation with/without Osimertinib treatment at 3 dpt. Hpf: hours postfertilization; dpt: days posttreatment.

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