α-1-Acid Glycoprotein Concentration as an Outcome Predictor in Adult Patients with Sepsis

Table 4

Association between AGP levels and other manifestations in patients with sepsis (survivors and non-survivors).

	Survivors	Non-survivors	Crude OR	p value	Adjusted OR	p value
	n=68	n=19	(95% CI)		(95% CI)
Age (y) (mean ± SD)	64.0 ± 15.4	69.5 ± 12.3		0.16	−
Male/Female (n)	45/23	14/5	1.43 (0.46-4.47)	0.59
Potential diseases [n (%)]
Diabetes	19 (27.9)	9 (47.4)	2.32 (0.82-6.60)	0.16
Hypertension	36 (52.9)	9 (47.4)	0.80 (0.29-2.22)	0.80
Chronic lung disease	7 (10.3)	2 (10.5)	1.02 (0.20-5.40)	1.00
Cerebrovascular disease	9 (13.2)	3 (15.8)	1.23 (0.30-5.08)	1.00
Chronic heart disease	3 (4.4)	2 (10.5)	2.55 (0.39-16.5)	0.64
Chronic renal disease	15 (22.1)	7 (36.8)	2.06 (0.69-6.16)	0.24
Clinical presentations (mean ± SD)
Systolic BP (mmHg)	95.3 ± 33.8	96.8 ± 35.9		0.87
Heart rate (bpm)	109.2 ± 25.5	114.0 ± 28.3		0.48
Shock within 24 hours [n (%)]	53 (77.9)	18 (94.7)	5.09 (0.63-41.3)	0.18
Clinical severity index (mean ± SD)
Maximum 24-h APACHE II score	19.1 ± 6.7	23.5 ± 9.1		0.02	1.13 (1.01-1.26)	0.04
Bacteremia [n (%)]	27 (39.7)	6 (31.6)	1.15 (0.24-2.01)	0.70
Intervention within 24 hours [n (%)]
Mechanical ventilator	18 (26.5)	12 (63.2)	4.76 (1.62-13.9)	0.01
Vasoactive agent	5 (71.4)	1 (14.3)	0.07 (0.01-0.97)	0.10
Laboratory data (mean ± SD)
White blood cells (×10^9/L)	13.5 ± 7.5	17.9 ± 8.6		<0.05
Hemoglobin (mg/dL)	11.9 ± 2.0	11.9 ± 2.8		0.98
Platelet counts (×10^4/L)	182.6 ± 109.6	159.5 ± 84.0		0.40
C-reactive protein (mg/L)	156.9 ± 110.0	216.8 ± 89.6		0.02
Lactate (mg/dL)	29.1 ± 10.3	39.1 ± 13.2		<0.01	1.105 (1.02-1.2)	0.01
Cr (mg/dL)	2.1 ± 1.6	2.6 ± 2.4		0.28
GOT (mg/dL)	57.01 ± 41.8	60.6 ± 49.6		0.77
Procacitonin (mg/dL)	24.0 ± 26.7.	28.4 ± 32.2		0.67
AGP (ng/ml)	1039.0 ± 321.8	1491.8 ± 449.2		<0.01	1.005 (1.002-1.008)	<0.01

SD, standard deviation; APACHE, Acute Physiology and Chronic Health Evaluation