Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

Table 2

Summary of animal studies on platelet-rich fibrin in oral and maxillofacial bone regeneration.

Animal model	Intervention	Outcome	Reference
Implantation after tooth extraction in dogs	Implants with or without PRF	The presence of PRF resulted in higher BAFO histologically	[32]
Maxillary sinus floor elevation	Bovine and autogenous bone mixture or PRF	The bovine and autogenous bone group yielded better histological results than the PRF group	[33]
OPD in rabbits	Device + PRF, device, PRF, and sham	The device + PRF group presented the highest percentages of bone volume and bone area histologically and radiologically	[34]
Orthodontic relapse in rabbits	Control group, CHA, and CHA-A-PRF	Relapse rate and relapse distance were lower () in CHA-A-PRF. The number of osteoblasts was higher and that of osteoclasts was lower in CHA-A-PRF histologically	[35]
Periodontal bone defect in rats	No treatment, PRF, or PRF/aspirin complex.	New bone in the PRF/aspirin complex group was more than twice of that in the PRF group histologically	[36]