Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

Table 5

Summary of clinical effects of platelet-rich fibrin combined with drugs in oral and maxillofacial bone regeneration.

Patient number (age/range)	Disease type	Intervention	Follow-up	Outcome	Reference
72 (30−35 years)	Furcation defects	PRF (group II) or PRF + 1% ALN (group III)	9 m	PRF + 1% ALN showed a greater percentage of radiographic defect fill (56.01% ± 2.64%) compared with the PRF group (49.43% ± 3.70%) ()	[91]
20 (38−56 years)	Furcation defects (40 sites)	PRF group or PRF+1% ALN group	6 m	More mean reduction in radiographic bone defect volume for PRF + ALN (11.98 ± 4.13 mm^3) than the PRF group (8.65 ± 3.84 mm^3) ()	[92]
105 (25−55 years)	Furcation defects	Placebo gel (group I), PRF + HA (group II), or 1.2 mg RSV gel + PRF + HA (group III)	9 m	A greater percentage of radiographic mean bone fill was found in group II (54.69% ± 1.93%) compared with group III (61.94% ± 3.54%) and group I (10.09% ± 4.28%) ()	[93]
96 (30−50 years)	IBD	PRF or PRF + 1.2% ATV	9 m	PRF + ATV caused a greater percentage radiographic defect depth reduction compared with PRF alone ()	[94]