Different Methylation of CpG-SNPs in Behcet’s Disease

Table 4

Genotype and allele frequencies of CpG-SNP polymorphisms in BD and healthy controls (first stage study).

Target_ID	CpG-SNP	Genotype	BD n (%)	Controls n (%)	P value	Pc value	OR	95% CI
cg10181180	rs10454134	total sample	355	704
		AA	87 (0.245)	173 (0.246)	0.981	NS	0.996	0.741-1.340
		AG	195 (0.549)	326 (0.463)	0.008	NS	1.413	1.094-1.826
		GG	73 (0.206)	205 (0.291)	0.003	NS	0.630	0.465-0.854
		A	369 (0.520)	672 (0.477)	0.065	NS	1.185	0.989-1.420
		G	341 (0.480)	736 (0.523)			0.844	0.704-1.011
cg15835500	rs176249	total sample	357	702
		AA	13 (0.036)	25 (0.036)	0.947	NS	1.023	0.517-2.025
		AG	119 (0.333)	207 (0.295)	0.200	NS	1.196	0.910-1.572
		GG	225 (0.630)	470 (0.670)	0.203	NS	0.841	0.645-1.098
		A	145 (0.203)	257 (0.183)	0.266	NS	1.137	0.906-1.427
		G	569 (0.797)	1147 (0.817)			0.879	0.701-1.103
cg12480843	rs3808620	total sample	355	704
		GG	339 (0.955)	670 (0.952)	0.815	NS	1.075	0.585-1.976
		CG	16 (0.045)	33 (0.047)	0.895	NS	0.960	0.521-1.768
		CC	0 (0.000)	1 (0.001)	0.477	NS	/	/
		G	694 (0.977)	1373 (0.975)	0.742	NS	1.106	0.608-2.012
		C	16 (0.023)	35 (0.025)			0.904	0.497-1.645
cg08338478	rs10176517	total sample	354	703
		CC	190 (0.537)	415 (0.590)	0.096	NS	1.244	0.962-1.609
		CT	145 (0.410)	253 (0.360)	0.115	NS	0.810	0.624-1.053
		TT	19 (0.054)	35 (0.050)	0.787	NS	0.924	0.520-1.640
		C	525 (0.742)	1083 (0.770)	0.144	NS	1.169	0.948-1.441
		T	183 (0.258)	323 (0.230)			0.856	0.694-1.055
cg03157605	rs9461624	total sample	357	704
		GG	325 (0.910)	619 (0.879)	0.162	NS	0.739	0.484-1.130
		TG	32 (0.090)	84 (0.119)	0.182	NS	1.334	0.873-2.040
		TT	0 (0.000)	1 (0.001)	0.476	NS	/	/
		G	682 (0.955)	1322 (0.939)	0.122	NS	0.721	0.476-1.094
		T	32 (0.045)	86 (0.061)			1.386	0.914-2.102
cg16744961	rs10492166	total sample	358	696
		GG	123 (0.344)	251 (0.361)	0.584	NS	0.928	0.710-1.212
		GA	169 (0.472)	344 (0.494)	0.495	NS	0.915	0.709-1.181
		AA	66 (0.184)	101 (0.145)	0.098	NS	1.332	0.947-1.871
		G	415 (0.580)	846 (0.608)	0.212	NS	0.890	0.741-1.069
		A	301 (0.420)	546 (0.392)			1.124	0.936-1.350
cg00254095	rs6507921	total sample	358	677
		CC	103 (0.288)	232 (0.343)	0.072	NS	1.291	0.977-1.705
		CT	181 (0.506)	308 (0.455)	0.121	NS	0.816	0.632-1.055
		TT	74 (0.207)	137 (0.202)	0.869	NS	0.974	0.709-1.337
		C	387 (0.541)	772 (0.570)	0.196	NS	1.128	0.940-1.353
		T	329 (0.459)	582 (0.430)			0.887	0.739-1.064