[Retracted] Serum Exosomal MicroRNAs Predict Acute Respiratory Distress Syndrome Events in Patients with Severe Community-Acquired Pneumonia
Table 1
Baseline characteristics and outcome parameters in SCAP patients with and without ARDS.
Variables
ARDS (n=24)
Non-ARDS (n=29)
P value
Age (yrs)
59.63 ± 15.86
62.47 ± 12.10
0.078
Sex ( men)
18 (76%)
19 (67%)
0.209
APACHE II score
16.08 ± 9.41
12.83 ± 9.01
0.205
SOFA score
5.67 ± 3.55
4.45 ± 3.34
0.208
PSI
97.79 ± 28.38
95.31 ± 21.39
0.031
PaO2/FIO2 ratio
170.26 ± 105.49
226.47 ± 88.86
0.04
Co-morbidities
(i) Pulmonary embolism, n (%)
2 (8%)
4 (14%)
0.541
(ii) Hypertension, n (%)
10 (42%)
10 (34%)
0.6
(iii) Diabetes mellitus, n (%)
6 (25%)
6 (21%)
0.715
(iv) COPD, n (%)
3 (13%)
9 (31%)
0.113
(v) Cardiovascular/cerebrovascular diseases, n (%)
6 (25%)
6 (21%)
0.715
Complication
(i) Sepsis
7 (29%)
7 (24%)
0.686
(ii) AKI
3 (13%)
4 (14%)
0.893
Platelet count (×109/L)
181.5 ± 77.61
197.9 ± 108.9
0.539
28-day mortality
12 (50%)
10 (34%)
0.262
Microbiological species
(i) Streptococcus pneumoniae
6 (25%)
6 (21%)
0.715
(ii) Haemophilus influenzae
1 (4%)
2 (7%)
0.676
(iii) Legionella pneumophila
0 (0%)
1 (3%)
0.368
(iv) Mycoplasma pneumoniae
1 (4%)
4 (14%)
0.241
(v) Other
9 (39%)
6 (21%)
0.151
(vi) unknown
7 (29%)
5 (17%)
0.311
Invasive mechanical ventilation, n ()
16 (67%)
13 (45%)
0.116
PEEP (cmH2O)
7.04 ± 4.73
4.86 ± 0.833
0.092
Hospital stay, days
20.17 ± 8.25
16.41 ± 8.42
0.109
Laboratory parameters
(i) CRP (mg/dl)
90.27 ± 72.15
75.3 ± 58.43
0.408
(ii) Procalcitonin
1.75 ± 4.29
1.55 ± 3.76
0.858
(iii) Ang2 (ng/ml)
7.55 ± 1.67
5.08 ± 0.65
0.149
(iv) IL-6 (pg/ml)
62.04 ± 13.39
13.61 ± 2.01
0.002
(v) IL-10 (pg/ml)
10.66 ± 1.04
26.1 ± 7.53
0.07
(vi) vWF (% of control)
449.64 ± 118.45
266.64 ± 18.24
0.001
Data were presented as n (%), mean ± standard deviation. P value <0.05 was considered as statistically significant. APACHE II, Acute Physiology and Chronic Health Evaluation II score; CRP, C-reactive protein; PSI, pneumonia severity index; SOFA score, Sequential Organ Failure Assessment score; CRP, C-reactive protein; PSI, pneumonia severity index; PEEP, positive end-expiratory pressure; Ang-2, angiopoietin 2; vWF, von Willebrand factor.
